Mitchell and George are two ordinary guys. They both work as porters in a hospital in Bristol and share a house together. Well, maybe Mitchell and George aren’t exactly ordinary guys considering that Mitchell is a vampire and George is a werewolf. Oh, and the house they rent together? It just happens to be haunted by a ghost named Annie.
After Mitchell almost kills a co-worker named Lauren during a date and the only way to save her is to turn her into a fellow vampire, Mitchell becomes disgusted with himself and decides he needs to make a change. Mitchell had suffered from guilt over killing people to feed for many decades and even managed to ‘go clean’ during the 1960’s but at some point he ‘fell off the wagon’. Deciding to get clean again and stop drinking blood, he convinces his werewolf friend George that the two of them should rent a house together, becoming part of a community in the hopes of fitting in and living like regular humans.
George is reluctant at first, stating that he and Mitchell are monsters and therefore could never fit in with normal humans but he is soon convinced to give it a try and falls in love with a house the pair go to look at. Upon moving in strange things begin to happen in the house, most notably a roasting chicken being nailed to the cupboards and the words ‘GET OUT’ scrawled on the walls. It’s not long before the guys discover who is responsible for the mischief, a ghost named Annie who had died in the house after falling down the stairs a year earlier. The house belonged to Annie and her fiancée Owen and after her death Annie could not bear to share the house with the living so she terrorized whomever moved in until they were forced to leave.
When Annie realizes that both Mitchell and George can see her she is thrilled to bits as she is no longer alone without people to talk to. Mitchell mentions that the reason Annie can be seen by he and George is because all supernatural creatures such as vampires, ghosts and werewolves are able to recognize each other. At first George isn’t happy about sharing the house with a ghost but Annie soon grows on him. Together the three find comfort in each others company.
Things don’t always go smoothly for the trio. When Lauren begins stalking Mitchell he soon realizes that it was a mistake to sire her. Lauren claims to be happy about being a vampire but she is obviously bitter. She blames Mitchell for everything that she had done while a vampire including killing her first boyfriend. At one point Lauren reaches out to Mitchell in the hopes that he would help her to get clean and stop killing. Mitchell, feeling obligated to help her, lets Lauren feed from him for a time in order to slate her thirst so that she no longer need kill. Mitchell then tries to help Lauren to quit completely but the thirst proves too strong. She begs him to get her some donated blood from the hospital in order to feed and Mitchell reluctantly agrees. Unfortunately, the blood is no good to vampires since it is not fresh from the kill. Mitchell tries to tell Lauren this but she refuses to believe him until she tries drinking the blood and finds it useless. Deciding that her will is just not strong enough to quit, Lauren leaves Mitchell and returns to Herrick, the leader of Bristol’s vampires and Mitchell’s sire whom Mitchell has had on ongoing feud with for decades.
The vampires of Bristol are not happy with Mitchell and consider him a betrayer to vampire kind since he refuses to kill and would rather spend his time hanging around a werewolf rather than his own people. Herrick wants nothing more than to bring Mitchell back into the fold and will do whatever it takes but with George and Annie at his side Mitchell has the strength to resist temptation. That is of course until be makes friends with a neighbourhood boy named Bernie and everything goes to hell.
Mitchell first meets Bernie when he steps in while Bernie is being harassed by other neighbourhood boys. The two quickly strike up a friendship which is encouraged by Bernie’s mother. While having the boy over at the house Mitchell mentions his fondness for Laurel and Hardy. Not knowing who Laurel and Hardy are, Mitchell offers to lend Bernie a DVD promising the boy that he will never laugh so hard. What Mitchell fails to realize is that Bernie picks a movie that has the wrong DVD inside. Instead of a Laurel and Hardy movie the case holds a DVD of vampire porn made by Lauren in the hopes of enticing Mitchell back into the fold. Since vampires cannot be seen in reflection or be recorded the DVD only pictures a man gyrating on a bed by himself in a sexual nature. The DVD ends with Lauren killing the man and her bloody footprints walking away from the body.
When Bernie’s mother catches her son watching the DVD she gets the entire neighbourhood whipped up into a frenzy claiming that Mitchell and George are a pair of paedophiles. Not giving Mitchell the chance to explain that giving Bernie the DVD was a horrible accident and not intended, the neighbourhood goes about making life hell for he and George. Meanwhile Annie has problems of her own when she discovers that her death was not an accident but that she was actually murdered by her fiancée Owen when he threw her down the stairs in a fit of rage.
Annie realizes that the reason that she had not ‘crossed over‘ was that she needed to make Owen confess to what he had done. When Owen comes around to the house and informs the guys that he is kicking them out due to the controversy in the neighbourhood Annie is even more determined to make him pay and George agrees to help her. Together the two devise a plan to frighten Owen into confessing.
The resentment from the neighbours proves too much for Mitchell who secretly returns to Herrick and the other vampires. After Bernie is accidentally hit by a car during a riot outside the house, Mitchell confronts Bernie’s mother and offers to save the boy by turning him into a vampire. She agrees and in return informs the rest of the neighbourhood that she was mistaken and that Mitchell was innocent all along. Knowing that their actions caused the death of the little boy they claimed to be protecting the rest of the neighbourhood soon begins to try and make amends. After Bernie is declared dead he and his mother leave Bristol in hopes of starting a new life together.
Herrick has plans to make vampires the master race and with Mitchell back on board the vampires have access to patients within the hospital, offering immortality to the terminally ill in order to increase their numbers. Soon Herrick will have an army and will be able to declare war on the human race and Mitchell will be standing by his side as his second in command. Mitchell, enraged by the needless death of a young child decides that humans aren’t worth the trouble and gradually begins to alienate himself from George and Annie.
George and Annie put their plan to make Owen confess in motion when George calls Owen over to the house to do some repairs. When Owen arrives he is confronted by Annie who commands him to confess. Owen’s reaction is not what Annie expects when instead of being afraid of the ghost of his murdered fiancée Owen begins to belittle her. Annie then redoubles her efforts by haunting Owen’s new girlfriend Janie in hopes of warning her of the dangers of dating Owen. Janie has a much more normal reaction to seeing a ghost when she freaks out and faints. Annie almost manages to reach Janie when Owen returns home and convinces Janie that Annie is simply a figment of her imagination caused by her guilt over the affair she and Owen were having while Annie was still alive.
When George is confronted by an old flame of Mitchell’s named Josie who is dying of lung cancer she tells him what the vampires have been planning. She tells George that she had been approached by Herrick at Mitchell’s request and that Herrick had offered to recruit her, making her a vampire so that she will not die. However Josie does not see death as something to be feared and hopes that George will be able to interfere in order to help Mitchell. When George asks Josie just how bad the vampires plans are she informs him that Herrick had told her that “No one gets left behind.” George and Annie decided to raid the vampires’ lair in hopes of convincing Mitchell to come home with them. What they don’t realize is that Mitchell needs very little convincing after he stumbles upon a room filled with dying humans that the vampires have been holding captive in order to feed on.
Horrified by this revelation, Mitchell decides he no longer wants to be part of Herrick’s scheme and tries to escape the vampires’ lair underneath the funeral home that the vampires use as a front for their ‘recruitment‘ activities. Mitchell finds himself surrounded by angry vampires and it looks as if there is no way out but thankfully George and Annie show up just in time and with the help of Lauren the four of them manage to escape. Lauren only asks for one thing in return for helping Mitchell and his friends escape, she wants Mitchell to stake her and put her out of her misery as she can no longer bear being a monster. Mitchell reluctantly agrees and Lauren slowly turns to ash in his arms.
Back home Annie, Mitchell and George confront Owen together. When Annie informs Owen that there are much worse things than ghosts and implies that George is a werewolf and that Mitchell is a vampire, Owen’s bravado begins to fade. When Annie whispers a secret in his ear, something ‘only the dead know’, Owen goes over the edge completely and runs off. Terrified of what Annie had told him, he runs to the nearest police station and confesses to Annie’s murder in hopes of being safely locked away. Having finally been able to confront Owen, Annie’s door to the afterlife comes for her. As the three say their goodbyes there is a knock on the front door. As he answers the door, Mitchell is staked on the doorstep by Herrick who cannot enter the house without being invited.
George manages to push Herrick from the doorstep and pull Mitchell into the house. Frantically he calls for an ambulance to take Mitchell to the hospital. Annie refuses to enter the door to the afterlife and leave Mitchell behind and instead chooses to go with George and Mitchell. Doctors are able to stabilize Mitchell but are dumbfounded by the fact that they can’t find a heartbeat and that his wounds are healing too quickly. Despite multiple blood transfusions Mitchell is still unable to fully recover since he needs fresh blood to heal. Josie offers to let Mitchell feed from her since she will soon die and hopes that her sacrifice will help Mitchell to stop Herrick.
When Mitchell is released from the hospital he confronts Herrick and challenges him to a fight to the death. Mitchell insists that if Herrick manages to kill him Herrick is to allow George and Annie to leave Bristol safely. Herrick agrees yet has no intention on keeping his word. When George and Annie learn of Mitchell’s bargain they try to stop him. George convinces Mitchell to allow him to try and talk Herrick out of the fight but instead George informs Herrick that Mitchell will be waiting for him in the abandoned basement of the hospital. What Herrick doesn’t know is that George plans to confront him in the basement during the full moon when he transforms into a werewolf.
When Mitchell and Annie realize what George has planned they try to stop him but it’s too late. Mitchell tries to talk George out of killing Herrick but George will not be swayed. As George begins to transform his girlfriend Nina rushes in not knowing what’s going on. Mitchell and Annie are able to pull her out of the room but not before she is scratched by George. Once George’s transformation is complete he tears Herrick to pieces while Nina watches in shock.
The next morning George confides everything to Nina including how he became a werewolf. Nina chooses not tell George about the scratch from the night before in the hopes that she will not turn into a werewolf herself. Relieved that Herrick is dead Mitchell, George and Annie are hopeful that they can finally go about living ‘normal’ lives. What they don’t know is that there are people out there interested in the three of them and that someone has made contact with Owen who believes his claims that Annie, Mitchell and George are a ghost, a vampire and a werewolf.